PrEP+ was a club night series hosted by Frank Ocean in October 2019. Three events were held at BASEMENT at Knockdown Center in New York City, each featuring a different lineup of DJs, including Bouffant Bouffant, Justice, Sango, Sherelle, SXYLK, Leeon, Arca, Papi Juice, Shyboi, Joey Labeija, Vegyn, Last Japan, and DJ Heather. Tickets for the shows could be redeemed on blonded.world with an access code distributed by the performers. Blonded described the promotion in a press release:

PrEP+ is a series of nights; an ongoing safe space made to bring people together and dance. PrEP+ will welcome globally celebrated DJs. PrEP+ welcomes everyone.

The “blonded live radio events” on October 17th, 24th, and 31st coincided with the release of three Blonded Radio episodes—008, 009, and 10—and the sale of merchandise on blonded.co, including four 7-inch singles—“Cayendo,” “Dear April,” “In My Room,” and “Little Demon.”

The series took its name from the HIV prevention medicine Pre-Exposure Prophylaxis, commonly known as PrEP; however, despite some initial confusion over its title, it was not a sponsored event. After the first club night, Ocean posted an open letter on Tumblr explaining who funded the project and what had inspired it:

Not funded by Gilead Sciences [drug company]. Funded by Blonded, independently. Let’s just get that out of the way. Club culture around late 70s and 80s nightlife in NYC was a special, much-talked-about and written-about thing. From the star-studded midtown clubs like Studio 54 and the first danceteria to the downtown clubs like Mudd + Paradise Garage. The figures, the music, the looks, the lack of regulation haha. I recognize NY wasn’t all lasers and disco lighting, and that simultaneously, there was a lot of crime and poverty, and that a huge part of club culture, the gay community, at that time were being wiped out by HIV + AIDS. Now in 2019, there’s a pill you can take every day that will, at a better than 90% chance, prevent you from contracting HIV. This pill was approved by the FDA in 2012. The pricing strategy behind it is malicious, in my opinion, and so its public perception is marred and rightfully so. But the fact remains that, despite price being a very real barrier to this potentially life-saving drug for some, the other very real barrier is awareness. I decided to name what was otherwise going to be a night of lights and music inspired by an era of clubbing that I loved “PrEP+” because while designing the club—which is inside of an old glass factory basement in Queens (shoutout to the BASEMENT that runs a very awesome techno night on Fridays after us)—I started to imagine in an era where so many lives were lost and so much promise was lost forever along with them, what would it have been like if something, anything had existed that in all probability would’ve saved thousands and thousands of lives. I’m an artist, it’s core to my job to imagine realities that don’t necessarily exist, and it’s a joy to. A couple days before we threw the party, I was discussing this subject with my team, and one of the architects I work with thought that PrEP as a drug had reached “100% saturation” so far as awareness. I thought he was dead wrong, so I asked a friend (who I won’t name haha) if he knew what PrEP was, and his response was “isn’t that some type of viagra or something?” My ex who I was with for several years didn’t know about it when we first met at a gay club in LA. Awareness isn’t always what we’d hope it would be. But anyway, I’m ranting. I’m happy that folks are talking about the subject in the first place. Thank you to everyone who came out and danced with us last night. Y’all were beautiful, and the energy was right! Thank you Bouffant Bouffant, Sango, Justice, and Sherelle for your sets last night. They were so good man. Oh one more thing, I saw someone say that this was a PR stunt, etc., etc., pshhh bitch pls come get a drink next time, and I’ll put several barstools out so you can have as many seats as you need. All my love, everybody, really. Stay safe.

Ocean later expanded on his intentions for the project in a January 2023 letter:

Prior to the COVID-19 pandemic, these events were intended to grow from small club events to larger raves across the world.

Below is a list of all PrEP+ events; select a flyer or icon in the table to go to that show’s blog post.